Editing Prostate Cancer: Management of Locally Advanced Prostate Cancer (section)

====== ARO 96-02 ======
* German study
* Population: 368 patients with pT3 or pT4 but without nodal metastatic disease
* Randomized to adjuvant RT vs. observation
** A major difference in this trial from the previous two is that all patients had an undetectable PSA level before randomization. Patients in the salvage group underwent salvage therapy with radiation and/or hormone therapy on recurrence.
* Results:
** Biochemical progression–free survival rate was improved by 21% at 10-years in the adjuvant arm (56% adjuvant vs. 35% salvage) [2014 update, original publication 2009]
** No improvement in metastasis-free or overall survival
* Wiegel, Thomas, et al. "Adjuvant radiotherapy versus wait-and-see after radical prostatectomy: 10-year follow-up of the ARO 96–02/AUO AP 09/95 trial." European urology 66.2 (2014): 243-250. <nowiki>https://www.ncbi.nlm.nih.gov/pubmed/24680359</nowiki> [Original publication 2009]