Editing Prostate Cancer: Management of Locally Advanced Prostate Cancer (section)

== Radiation with long-term ADT ==
* '''Radiation with long-term ADT'''
** '''EBRT or EBRT + brachytherapy with concurrent long-term (18 to 36 months) ADT is recommended''' (2020 NCCN Guidelines PROS-7)
*** '''EORTC 22863 (Bolla et al. 1997)''' & '''RTOG 86-10'''
**** '''See Management of Localized Prostate Cancer Chapter Notes'''
*** '''The trials above have evaluated the benefit of adding ADT to radiation. It has been questioned whether the benefits of radiation plus ADT are superior to ADT alone for locally advanced disease. These trials have shown that ADT alone is inferior to ADT with radiation.'''
**** '''PR3/PR07 trial (Warde et al.)''' & '''SPCG-7/SFUO-3'''
***** '''See Management of Localized Prostate Cancer Chapter Notes'''
** The method of ADT does not affect the outcome of combined treatment with RT.
** The role of chemotherapy combined with RT is less well studied than that for surgery and chemotherapy.