Editing Adrenal: Pheochromocytoma (section)

==== Treatment of Malignant Pheochromocytoma ====
* '''Currently, malignant pheochromocytoma can only be defined by the presence of clinical metastases'''.
** A number of pathologic criteria to differentiate benign from malignant disease have been proposed, but to date there is no criterion agreed on.
*Currently therapy for metastatic pheochromocytoma is largely '''palliative'''.
* '''Surgical metastasectomy of resectable disease is the standard of care'''
** Little evidence exists to demonstrate that it prolongs patient survival or is more effective for symptomatic relief than medical treatment with α/β-blockade and α-methyl-p-tyrosine
* Chemotherapy is primarily used in patients in whom MIBG therapy has failed or in those whose tumors do not demonstrate MIBG uptake on initial MIBG imaging studies.